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the way to produce new labour union blokujacych h $2 histamine receptors
the way to produce new labour union blokujacych h $2 histamine receptors
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机译:生产新工会的方法blokujacych h $ 2组胺受体
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Heterocyclic guanidines and isothioureas of formula: Het-(CH2)3-NH.C(=N.Y).W-(CH2)q-W-C(=X)-NH(CH2)nZ(CH2)m-Het' (I) and their addition salts with pharmaceutically acceptable acids are new: In the formula Het = pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, pyrimidyl, pyrazinyl or pyridazinyl, opt. subst. by halo, lower alkyl or alkoxy, OH or NH2, Y = H, OH or lower alkyl, X = S, CHNO2 or NY', Y' = H, OH, lower alkyl, CN or CONH2, W = NH or equally, when NY and X are both NH, also S, q = 2-12, n = 2-3, m = 0-2, provided that m+n = 3-4, or m+n can also be 2 when X is NH, NOH, NCONH2 or N alkyl and Het' = imidazolyl, pyrazolyl or triazolyl. Z = S or CH2, Het' = 5-6 membered N-heterocycle e.g. as defined for Het, imidazolyl, triazolyl or pyrazolyl, opt. substd. as for Het. Pref. cpds. have W = X=NH Y = H and q=6-10. (I) block the H2 histamine receptors which are not blocked by conventional antihistamines such as mepyramine. They are thus useful as antisecretories, antiphlogistics and cardiovascular agents. The usual daily dose is 0.15-1.5g.
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机译:式:Het-(CH2)3-NH.C(= NY).W-(CH2)qWC(= X)-NH(CH2)nZ(CH2)m-Het'(I)的杂环胍和异硫脲与药学上可接受的酸形成的加成盐是新的:式中Het =吡啶基,噻唑基,异噻唑基,恶唑基,异恶唑基,噻二唑基,嘧啶基,吡嗪基或哒嗪基。替代通过卤素,低级烷基或烷氧基,OH或NH 2,Y = H,OH或低级烷基,X = S,CHNO2或NY',Y'= H,OH,低级烷基,CN或CONH2,W = NH或相等,当NY和X均为NH时,S也为q = 2-12,n = 2-3,m = 0-2,前提是m + n = 3-4或m + n也可以是2 NH,NOH,NCONH2或N烷基,Het'=咪唑基,吡唑基或三唑基。 Z = S或CH2,Het'= 5-6元N-杂环,例如如对Het,咪唑基,三唑基或吡唑基所定义。取代至于Het。首选cpds。 W = X = NH Y = H且q = 6-10 (I)阻断未被常规抗组胺药如美吡拉明所阻断的H 2组胺受体。因此,它们可用作抗分泌剂,消炎药和心血管药物。通常的每日剂量是0.15-1.5g。
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