首页> 外国专利> 1,3-DIOXO-2-ISOINDOLINEACETIC ACID, N-(2-BENZOYL-PHENYL)-1, 3-DIOXO-2-ISOINDOLINEACETAMIDO METHYLENE HYDRAZIDES

1,3-DIOXO-2-ISOINDOLINEACETIC ACID, N-(2-BENZOYL-PHENYL)-1, 3-DIOXO-2-ISOINDOLINEACETAMIDO METHYLENE HYDRAZIDES

机译:1,3-二氧杂-2-异吲哚啉乙酸,[[N-(2-苯甲酰基-苯基)-1,3-二氧杂-2-异吲哚基乙酰胺]亚甲基]酰肼

摘要

ABSTRACT OF THE DISCLOSUREA multistep process is disclosed for the productionof a compound of the formula V:Vwherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusiveor together is pyrrolidino, piperidino, 4-methylpiper-azino or morpholino; and wherein the rings A and B are unsub-stituted, or substituted by one or more substituents selectedfrom the group consisting of fluoro, chloro, bromo, nitro andtrifluoromethyl. Compounds of formula V are used for treatmentof anxieties and/or depressions in mammals and birds. Thisdivisional application is directed to the production of inter-mediate compounds of the formula II:wherein R1 is hydrogen or halogen. The process comprises treatingone mole of a compound of the formulain an inert organic solvent with two mole equivalents of.alpha.-phthalimidoacetyl chloride or bromide in the presence of abase at -5° to 15°C.
机译:披露摘要公开了用于生产的多步骤方法式Ⅴ化合物的结构式:V其中R'和R“是1-3个碳原子的烷基或一起是吡咯烷基,哌啶子基,4-甲基哌啶叠氮或吗啉代;并且其中环A和B不为亚-被一个或多个选择的取代基取代或取代选自氟,氯,溴,硝基和三氟甲基。式V化合物用于治疗哺乳动物和鸟类的焦虑和/或抑郁症。这个分案申请是针对内部介导式Ⅱ化合物:其中R1是氢或卤素。该过程包括治疗一摩尔的下式化合物在惰性有机溶剂中,两摩尔当量的α-邻苯二甲酰亚胺基乙酰氯或溴化物存在下在-5°至15°C的基础上。

著录项

  • 公开/公告号CA1051905A

    专利类型

  • 公开/公告日1979-04-03

    原文格式PDF

  • 申请/专利权人 UPJOHN COMPANY (THE);

    申请/专利号CA19780310228

  • 发明设计人 HESTER JACKSON B. (JR.);GALL MARTIN;

    申请日0000-00-00

  • 分类号C07D209/48;

  • 国家 CA

  • 入库时间 2022-08-22 20:14:02

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