Preparation of an immuno - globulin the hepatitis b and use as a prophylactic substance

摘要

A method for producing a novel immunizing agent is described. The immunizing agent is anti-HBs gamma globulin essentially free of fibrinogen, plasminogen, 19 S globulin and lipids found to be effective in immunizing against hepatitis B virus disease. The method of producing this material involves fractionation of human plasma utilizing selective solvent and control of pH, temperature and ionic strength.