Anti:asthmatic methyl-xanthine compsns. - synergised with beta-sympathomimetic agents

摘要

New antiasthmatic compsns. comprise (a) a methylxanthine (e.g. theophylline and aminophylline) and (b) a much lower concn. of =1 beta-sympathomimetic agents salbutamol and terbutaline. Strong bronchodilator effect medicated via cyclic AMP and cyclic GMP. Intracellular cyclic AMP levels are increased by inhibition of phosphodiesterase by methyl xanthines, and by liberation of adenyl cyclase at the levels of the adrenergic bioreceptors by beta-symphathomimetic agents. Synergy is shown. A typical antiasthmatic tablet, dose 2-3 tablets daily, contained 100 mg of aminophylline, 2 mg of terbutaline sulphate and 50 mg of thiazinamium.