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Radio-iodinated tyrosine derivs. of oestradiol oxime cpds. - useful as reagents for radioimmunoassay of oestradiol
Radio-iodinated tyrosine derivs. of oestradiol oxime cpds. - useful as reagents for radioimmunoassay of oestradiol
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机译:放射性碘的酪氨酸衍生物。雌二醇肟cpds。 -用作雌二醇放射免疫分析的试剂
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摘要
Oestradiol derivs. of formula (I) are new. (where R = tyrosine residue, tyrosine 1-6 C alkyl ester residue, radioiodinated tyrosine residue, or radioiodinated tyrosine 1-6 C alkyl residue). Cpds. (I) in which R is a radioiodinated tyrosine or tyrosine alkyl ester residue are useful as reagents for the radioimmunoassay of oestradiol; in a highly specific manner, they form complexes with oestradiol antibodies. Other cpds. (I) are useful as intermediates for the radio-iodinated cpds. A procedure for carrying out a radio-immunoassay with the new cpds. is described in the specification. Specific cpds. (I) include that in which R is a tyrosine methyl ester residue. In an example, this is prepd. by reacting 6-(carboxymthoxyimino)-oestradiol with isobutyl chlorocarbonate in dioxan in the presence of tributylamine and reacting the resulting mixed anhydride with L-tyrosine methyl ester. Reaction of the product with Na125I in the presence of chloramine T and hydrolysis with NAOH gives (I) in which R is a 125I-tyrosine residue.
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