3-Pyridyl-thiazoline-2-thione derivs of formula (I) are new In (I), (a) R1 is H, 1-2C alkyl or methoxymethyl, R2 is 1-2C alkyl in position 4,5 or 6 and R3 is methyl, or (b) R3 is H and R1 is H, 1-4C alkyl or 1-4C opt. branched alkoxy methyl and R2 is 1-4C alkyl in position 4,5 or 6 or R1 is cyclopropyl and R2 is H. (I) are anti-ulcer cpds which are active in rats at doses of 5-100 mg/kg p.o (Rossi and Shay tests) and in guinea pigs at the same dose levels (Anderson and Watt test). Oral LD50 N 100 mg/kg.
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机译:式(I)的3-吡啶基-噻唑啉-2-硫酮衍生物是新的在(I)中,(a)R 1为H,1-2C烷基或甲氧基甲基,R2为4,5或6位的1-2C烷基,并且R 3为甲基,或(b)R 3为H且R 1为H,1-4C烷基或1-4C opt。支链烷氧基甲基,R2为4,5或6位的1-4C烷基,或R1为环丙基,R2为H。(I)是抗溃疡药,在大鼠中的剂量为5-100 mg / kg po(罗西(Rossi)和谢伊(Shay)试验)和豚鼠在相同剂量水平下(安德森和瓦特试验)。口服LD50 N 100 mg / kg。
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