MOVEL 55PHENYLPYRAZOLEEDERIVATIVE*ITS MANUFACTURE AND DRUG CONTAINING IT AND HAVING BLOOD LIPID DECREASE ACTIVITY AND ANTIALLURGIC ACTIVITY

摘要

The 5-phenylpyrazole derivatives which have the formula IMAGE in which R1 and R2 are a hydrogen or chlorine atom or a trifluoromethyl group, R3 is a hydrogen atom or a phenyl, benzyl or lower alkyl radical, R4 is a hydrogen atom or a methyl radical, R5 is a lower alkyl radical and A is carboxyl, alkoxycarbonyl, cyano and optionally substituted aminocarbonyl, have good lipid-lowering properties. They are suitable as long-term therapeutics because no liver changes occur. The corresponding 3-phenyl-5-pyrazolinones are suitable as starting materials for the preparation of these compounds.