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PROCEDURE FOR IMPROVING THE SOLUBILITY OF BIOLOGICALLY ACTIVE SUBSTANCES IN WATER AND LOWER ALIPHATIC ALCOHOLS AND RELATIONSHIPS WITH IMPROVED SOLUBILITY AND THEIR PREPARATION
PROCEDURE FOR IMPROVING THE SOLUBILITY OF BIOLOGICALLY ACTIVE SUBSTANCES IN WATER AND LOWER ALIPHATIC ALCOHOLS AND RELATIONSHIPS WITH IMPROVED SOLUBILITY AND THEIR PREPARATION
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机译:改善水中生物活性物质和低级醇的溶解度的方法及其与溶解度的关系及其制备方法
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摘要
1. Compounds, characterized in that active compounds which have a biological action and have at least one hydrogen atom which is active in Zerewitinoff reactions are reacted with a hydrophilic polyester which contains one OH-, NH- or NH2 -group and has a water absorption capacity of at least 10 %, relative to the weight of the polyether, and a compound of the formula (II) see diagramm : EP0017772,P13,F1 in which X and Y are identical or different and represent halogen, halogenoalkoxy, alkoxy, alkylmercapto, halogenoalkylmercapto, aryloxy or together represent alkylenedioxy, and Z represents -O-, -S-, or N-R, wherein R represents linear or branched alkyl with 1 to 18 C atoms, or phenyl or naphthyl which is optionally monosubstituted or polysubstituted by halogen, alkyl, alkoxy, alkylmercapto, halogenoalkyl, halogenoalkylmercapto or phenoxy, wherein either a) the polyether is first reacted with the compound of the formula (II) in an equivalent ratio of 1:1 and the resulting compound is reacted with the active compound in a molar ratio of 1:1 or b) the active compound is reacted with the compound of the formula (II) in an equivalent ratio of 1:1 and the resulting compound is reacted with the polyether or c) the active compound, the polyether and the compound of the formula (II) are reacted in an equivalent ratio of 1:1.
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