CEPHALOSPORINS WITH IMIDAZOLINONE SUBSTITUENTS IN THE 7-AND 1,2,4-THIADIAZOLYL-SUBSTITUENTS IN THE 3-POSITION,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Novel cephalosporins of the formula IMAGE in which R1 represents hydrogen, alkyl or acyl and R2 represents hydrogen, alkyl or aryl and which can be present with respect to the centre of chirality C* in the two possible configurations R and S and as mixtures of the diastereomers resulting therefrom, and their non-toxic, pharmaceutically tolerable salts are prepared. These compounds are obtained by reacting an appropriate cephalosporin, which has an acetoxymethyl group in the 3-position, with a 5-mercapto-1,2,4-thiadiazole substituted in the 3-position by R1 in the presence of a base. Resulting compounds can be converted into the free acid and pharmaceutically tolerable salts. The novel cephalosporins are used as medicaments, in particular as antibacterial agents in infectious diseases.