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METHOD FOR THE PREPARATION OF A PREPARATION WITH BLOOD PRESSURE REDUCING ACTION AND METHOD FOR PREPARING THE COMPOUNDS TO BE USED THEREOF
METHOD FOR THE PREPARATION OF A PREPARATION WITH BLOOD PRESSURE REDUCING ACTION AND METHOD FOR PREPARING THE COMPOUNDS TO BE USED THEREOF
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机译:一种具有降血压作用的制剂的制备方法及其所用化合物的制备方法
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摘要
A series of novel 2-amino and 4-aminoquinazoline derivatives have been prepared, including their acid addition salts. These derivatives all possess a single nitrogen-containing benzo-fused heterocyclic ring moiety at either the 4- or 2- positions of the molecule, respectively, with the ring moiety being attached through the nitrogen atom to the aforesaid quinazoline nucleus. Such compounds are useful in therapy as highly potent antihypertensive agents. Methods for their preparation are described in detail, including various synthetic routes leading to the required novel intermediates.
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