Process for the preparation of new derivatives of Burgo (b) tiophéine.

摘要

1357212 Benzothiapine derivatives LABAZ 16 June 1972 [25 June 1971] 30032/71 Heading C2C Novel compounds of Formula I and the pharmaceutically acceptable acid addition salts thereof, for example the oxalate or hydrochloride, wherein R represents hydrogen or a branched or straight-chain alkyl group containing from 1 to 4 carbon atoms, RSP1/SP represents hydrogen or methyl, X and X 1 , which are identical, each represent an atom of chlorine, bromine or iodine, Am represents a dimethylamino, diethylamino, di - n - propylamino, di - n - butylamino, pyrrolidino, piperidino or perhydroazepino group, and n is an integer in the range of from I to 5 inclusive are prepared by reaction of HAm with a compound of Formula IV or in the case where n is 1 or 2 by reaction of a compound II with (Z is halogen or tosyloxy). Intermediates of Formula IV above are prepared by reaction of with an intermediate of Formula II above obtained by the demethylation of the corresponding methyl ether starting material followed by halogenation. Pharmaceutical compositions in conventional forms for oral or rectal administration comprise an above novel compound and a carrier or diluent. The compositions are of use in the treatment of heart conditions.