6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acid derivatives having the formula IMAGE wherein R is a methyl, phenyl or benzyl radical, Z1 is a hydrogen atom and Z2 is a radical selected from those known from penicillin chemistry and is preferably a 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl radical, or Z1 and Z2 together represent a bivalent radical Z3 and preferably a (hexahydro-1H-azepin-1-yl)methylene radical, as well as the pharmaceutically acceptable non-toxic salts thereof and process for preparing the same. These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.
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