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Method of preparing an intravenously administrable immune globulin preparation containing antibodies and preparations produced according to this method
Method of preparing an intravenously administrable immune globulin preparation containing antibodies and preparations produced according to this method
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机译:制备含有抗体的静脉内施用的免疫球蛋白制剂的方法以及根据该方法制备的制剂
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摘要
A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin-containing fraction is freed from undesired protein impurities by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-containing fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treatment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from protein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharmaceutical preparation.
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