Symm. phenyltris(sulfonylimino)tri-benzene sulfonic acids and salts, a method of inhibiting the complement system in a body fluid with such a compound, a method for the preparation of such compounds and a pharmaceutical composition comprising such a compound

摘要

There are provided s-phenyltris (sulfonylimino) tri- benzene mono- and di-sulfonic acids and their salts which are useful as complement inhibitors. The novel compounds have the general formula:wherein each R is selected from the group consisting of hydrogen and alkali metal; each R₁, R₂ and R₃ is selected from the group consisting of hydrogen and SO₃A, wherein A is selected from the group consisting of hydrogen and a pharmaceutically acceptable salt cation; provided that at least one of the R₁, R₂ and R₃ groups on each phenyl is SO₃A; and further provided that when R₂ is SO₃A. R₁ and R, may not be SO₃A. E.g., these compounds may be prepared according to the following flowchart:wherein R' stands forThese compounds find utility as complement inhibitors in body fluids and as such may be used to ameliorate or prevent those pathological reactions requiring the function of complement and in the therapeutic treatment of warm-blooded animals having immunologic diseases.