Palmitoyl-propandiol-(1,3)-phosphoric acid-5-trimethylaminopentyl - ester, immunological adjuvant affecting cell membrane surface activity

摘要

Title cpd. has formula: Prepn. is (a) by reaction of propan-1,3-diol with palmitoyl chloride to give the monopalmitic acid ester (III); (b) (III) is then reacted with phosphoric acid mono-5-Br-pentyl ester dichloride to give propanediol-1-palmitic acid ester-3-phosphoric acid chloride-5-Br-pentyl ester (V); (c) V is reacted with NMe3 to replace the 5-Br and the acid chloride hydrolysed.