Coating auxiliary surgical materials - pref sutures with ionically bonded elastomeric block copolymers retaining anti-microbial cpds or dyes

摘要

Surgical auxiliary material (A) is coated anti-microbially with an ionic block elastomer of formula (I) (where R is 1-15C alkylene, R2 is low alkylene; R3,R4 and R5 are H and lower alkyl, R1 is a liq. prepolymer having mol. wt. 1000-3000 consisting of polyether, silicone, polyurethane or polyamide; Z and Y or OH or isocyanate gps. ZY is urethane gp. formed in condensation of Z and Y; n is integer 10-1000, B- is an anionic polymer and X is an anionic or cationic antimicrobial cpd). Dyed (A) coated with (I; X = anionic or cationic dye gp). and sterile suture material consisting of (A) coated with (I free from X) are also claimed. (A) pref. consist of surgical suture materials, dressings for wounds, fabrics and internal prostheses. Antimicrobial cpd. X added to sterile (I)-coated (A) is retained for a longer duration of use and is released slowly by action of water, blood or tissue-fluids, while bacterial growth in and around suture matl. is inhibited.