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1-Methyl 2-(phenyl oxymethyl) 5-nitro imidazoles - for control of protozoa, helminths and ectoparasites
1-Methyl 2-(phenyl oxymethyl) 5-nitro imidazoles - for control of protozoa, helminths and ectoparasites
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机译:1-甲基2-(苯氧甲基)5-硝基咪唑-用于控制原生动物,蠕虫和体外寄生虫
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摘要
New 1-methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles of formula (I) and their salts with physiologically compatible acids. (where R1-3 are H or 1-4C alkyl, or R1-C-N-R2 forms a pyrrolidine piperidine or hexamethyleneimine ring; or -NR2R3 forms a pyrrolidine, piperidine, morpholine or thiomorpholine ring), can be used to treat protozoon infestations in man and animals caused, e.g., by Trichomonas vaginalis and Entamoeba histolytica. They are also anthelmintics and act against ectoparasites e.g. ticks. (I) can be given orally or topically in conventional pharmaceutical prepns. A suitable oral dose is 10-750 mg.
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