Epinegamycin 2-(3R,5S-3,6-diamino-5-hydroxy-hexanoyl)-1-methyl-hydrazino-acet- ic acid of formula (II) as the racemic or optically active form with the absolute configuration (7R, 9S-correspond. to 3,5 positions of the hexanoyl radical) and its acid addn. salts are new. (II) is prepd. by catalytic hydrogenation of (III). In (III) A is an amine protecting group e.g. benzyloxycarbonyl which may be removed by hdyrogenolysis and B is an acid protecting group e.g. benzyl removal by hydrogenolysis. (II) are antibacterials effective against Gram-negative and Gram-positive organisms which may be administered orally, rectally, topically or pref. parenterally.
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