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DERIVATIVES HAVING AN INHIBITORY ACTION PROTEASE AND AN ANTIPHLOGISTIC ACTION OF THE TRYPSIN KALLIKREIN INHIBITOR OBTAINED FROM CATTLE ORGANS BPTI THEIR PREPARATION AND THEIRUSE AS MEDICAMENTS
DERIVATIVES HAVING AN INHIBITORY ACTION PROTEASE AND AN ANTIPHLOGISTIC ACTION OF THE TRYPSIN KALLIKREIN INHIBITOR OBTAINED FROM CATTLE ORGANS BPTI THEIR PREPARATION AND THEIRUSE AS MEDICAMENTS
The invention provides derivatives of kallikrein-trypsin inhibitor (BPTI) in which one or both of the 10- or 21-tyrosine residues are linked, in the o-position relative to the phenolic hydroxyl group, to an aptionally substituted carbocyclic or heterocyclic aromatic radical via an azo group and the other if only one of the said residues is substituted is either unsubstituted or carries a nitro group or an amino group in the o-position relative to the phenolic hydroxyl group.
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