4- 2-(2-Substituted phenyl)ethenyl!-N-alkenyl or alkinyl substituted 1,2, 3,6-tetrahydropyridines

摘要

Compounds of the formula and their pharmaceutically acceptable acid addition salts ##STR1## wherein X is lower alkoxy, Cl, Br, or F; R is ##STR2## or --C.tbd.C--R.sub.4 ; R.sub.1, R.sub.2, R.sub.3, and R.sub. 4 are independently selected from hydrogen and methyl; n is an integer from 1 to 3 provided that when n is 3 at least two of R.sub.1, R.sub.2 and R. sub.3 are hydrogen and R.sub.4 is hydrogen, and further provided that when n is 2 at least one of R.sub.1, R.sub.2 and R.sub.3 is hydrogen; are disclosed. These compounds possess useful pharmaceutical activities due to their ability to inhibit the prostaglandin-inactivating enzyme 15-. alpha.-hydroxyprostaglandin dehydrogenase.