100HYDROXYY10*5 IMINOMETHANO 5H*10HHDIBENZO A*D CYCLOHEPTENN111ONE COMPOUND

摘要

NEW MATERIAL:The titled compound of formula I (R is H or lower alkyl). EXAMPLE:12-Formyl-10-hydroxy-10,5( iminomethano )-5H,10H-dibenzo[ a,d ]-cyclohepten-11-one. USE:An analgesic agent having higher analgesic activity than aminopyrine which is a non-narcotic antipyretic and analgesic agent. PROCESS:The compound of formula I wherein R is lower alkyl is prepared by oxidizing 5-amidomethyl-5H-dibenzo[a,d]cycloheptene of formula II (R1 is H or alkyl having smaller carbon number than R by one) and then reducing the 12-position carbonyl group of the resulting 10-hydroxy-10,5-(iminomethano)-5H,10H-dibenzo [a,d]-cyclohepten-11-one compound to methylene group.