NOVEL 88SUBSTITUTED CYCLOHEXENYLFLAVONE DERIVATIVE OBTAINED FROM PLANT OF GENUS MORUS

摘要

NEW MATERIAL:The titled compound extracted and isolated from a plant of the genus Morus [kuwanon G[Elementary analysis (%): C, 66.95; H, 5.30. Melting point (decomposition): 213-219 deg.C. Specific rotatory power: [alpha]D22=-534 deg. (C= 0.232, methanol)] and kuwanon H [Elementary analysis (%): C, 69.62; H, 5.85. Melting point (decomposition): 186-190 deg.C. Specific rotatory power: [alpha]D22= -536 deg. (C=0.166, methanol)]. Both are light yellow noncrystalline solid. Positive to the ferric chloride and magnesium chloride reactions, etc.]. USE:A hypotensive agent. PROCESS:An extract from a plant of the genus Morus is treated with the polyamide resin column chromatography using a mixed solvent of water with a polar solvent as an eluting solvent and subjected to the silica gel column chromatography and silica gel separating thin layer chromatography to isolate and purify the titled compound. The compound is assumed to be a compound of formula I or II (R is H or formula III).