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66* 11* AND 22SUBSTITUTEDD11CARBADETHIAPENEE 22EMM33CARBOXYLIC ACID
66* 11* AND 22SUBSTITUTEDD11CARBADETHIAPENEE 22EMM33CARBOXYLIC ACID
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机译:66 * 11 *和22取代的D11碳三烯22EMM33羧酸
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摘要
Disclosed are 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: IMAGE wherein: R1, R2, R6, R7 and R8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
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