RUNNING TOY CHANGING FACE EXPRESSION

• 1. 一种跟随用户脸部表情改变角色模型表情的方法和终端 [P] . 中国专利： CN105797375A . 2016-07-27
• 2. 一种可随时自主改变生物脸部表情以及头部造型的壳体 [P] . 中国专利： CN201976361U . 2011.09.14
• 3. DEVICE FOR CHANGING DIRECTION OF RUNNING TOY AND RUNNING TOY [P] . 日本专利： JP2002239259A . 2002-08-27

  机译： 改变玩具的方向和玩具的装置

• 4. CHILDS BALL TOY WITH CHANGING FACIAL EXPRESSIONS AND FEATURES [P] . 世界知识产权组织专利： WO2019180397A1 . 2019-09-26

  机译： 具有变化的面部表情和功能的小球玩具

• 5. DOLL TOY CAPABLE OF BEING DECORATED IN VARIOUS STYLES BY CHANGING FACIAL EXPRESSIONS AND APPEARANCE [P] . 韩国专利： KR20190020564A . 2019-03-04

  机译： 可以通过改变面部表情和外观来装饰各种风格的公仔玩具

• 1. Why forefoot striking in minimal shoes might positively change the course of running injuries [J] . Irene S. Davis, Hannah M. Rice, Scott C. Wearing 运动与健康科学（英文版） . 2017,第002期
• 2. Minimalistic Toy Robot Encourages Verbal and Emotional Expressions in Autism [C] . Irini Giannopulu, Valerie Montreynaud, Tomio Watanabe International Conference on Advances in Computer-Human Interactions . 2016
• 3. Restaurant Response to the San Francisco Toy Ordinance: Changes in Toy Marketing and Children's Menu Options. [D] . Diedrich, Sara. 2015
• 4. Alteration in TRPV1 and Muscarinic (M3) Receptor Expression and Function in Idiopathic Overactive Bladder Urothelial Cells (Running title: Changes in TRPV1/M3 expression and function in human OAB urothelial cells) [O] . Lori A. Birder, Amanda S. Wolf-Johnston, Yan Sun, -1
• 5. Treadmill Running Changes Endothelial Lipase Expression: Insights from Gene and Protein Analysis in Various Striated Muscle Tissues and Serum [O] . Agnieszka Mikłosz, Bartłomiej Łukaszuk, Adrian Chabowski, 2021

• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. Change in stature by walking and running at a preferred transition speed [J] . Shinichi Demura ,Takayoshi Yamada ,Tamotsu Kitabayashi . 健康（英文） . 2010,第12期
• 3. Medical management of pituitary adenomas:a study of ultrastructural changes and receptor expressions [J] . 吴哲褒 . 外科研究与新技术 . 2011,第3期
• 4. Changes of Protein Kinase Cα and Cyclin D1 Expressions in Pulmonary Arteries from Smokers with and without Chronic Obstructive Pulmonary Disease [J] . Min XAING ,Xiansheng LIU ,Daxiong ZENG . 华中科技大学学报（医学）（英德文版） . 2010,第002期
• 5. 悦跑圈CEO梁峰在“智慧悦跑——马拉松改变城市推介会”上的演讲 [C] . . 2016济南·中国智慧城市（国际）创新大会 . 2016
• 6. 脸部表情技术的研究与实现 [A] . 张琛 . 2015