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2 - cyanoethyl derivatives, acid, 2 - (n - benzoylamino) alkanoic, their preparation process and therapeutic application
2 - cyanoethyl derivatives, acid, 2 - (n - benzoylamino) alkanoic, their preparation process and therapeutic application
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机译:2-氰基乙基衍生物,酸,2-(正苯甲酰氨基)链烷酸,其制备方法和治疗应用
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摘要
New compounds useful as immunoregulatory and antineoplastic agents are amino-acid derivatives of formula: IMAGE (I) wherein: n is an integer from 1 to 5; R1 is a hydrogen atom, an alkyl group, a haloalkyl group, a halogen atom, a mercapto group, an alkylmercapto group, a hydroxy group, an alkoxy group, an acyloxy group, a carboxyl group, an alkoxycarbonyl group, an amino group, an alkyl-substituted amino group, an aryl-substituted amino group, an acylamino group, a haloalkoxycarbonylamino group, an alkanesulphonyl group, a nitro group or a cyano group (and, when n is an integer from 2 to 5, the radicals R1 may be the same or different); R2 and R3 may be the same or different and each is a hydrogen atom or an alkyl group; R4 is a hydrogen atom, an alkyl group, a cyano group, a cyanoalkyl group, a hydroxyalkyl group, an alkoxycarbonyl group, a carboxyl group, an aryl group, an aralkyl group, a mercaptoalkyl group, an alkylthioalkyl group, or a thioalkyl group (the free bond of the sulphur in said thioalkyl group being joined to the sulphur of another moiety of the same formula); and A is a hydroxy group, an alkoxy group, an amino group, an alkyl-substituted amino group (optionally halogen- or carbamoyl- substituted in the alkyl moiety), a hydrazino group, an alkyl- or aryl- substituted hydrazino group, a hydroxylamino group, an alkoxyamino group or an aralkyloxyamino group; and the pharmaceutically acceptable salts thereof.
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机译:用作免疫调节剂和抗肿瘤药的新化合物是下式的氨基酸衍生物:(I)其中:n是1至5的整数; n是1至5的整数。 R1是氢原子,烷基,卤代烷基,卤原子,巯基,烷基巯基,羟基,烷氧基,酰氧基,羧基,烷氧基羰基,氨基,烷基取代的氨基,芳基取代的氨基,酰基氨基,卤代烷氧基羰基氨基,链烷磺酰基,硝基或氰基(并且,当n是2至5的整数时,基团R1可以是相同或不同); R 2和R 3可以相同或不同,分别为氢原子或烷基。 R 4为氢原子,烷基,氰基,氰基烷基,羟烷基,烷氧羰基,羧基,芳基,芳烷基,巯基烷基,烷硫基烷基或硫代烷基。 (所述硫代烷基中的硫的自由键与相同式的另一部分的硫连接);并且A是羟基,烷氧基,氨基,烷基取代的氨基(在烷基部分中任选地被卤素或氨基甲酰基取代的),肼基,烷基或芳基取代的肼基,羟氨基,烷氧基氨基或芳烷氧基氨基;及其药学上可接受的盐。
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