PROCESS FOR THE PREPARATION OF THIADIAZOLO AND OXADIAZOLOTETRAHYDROISOCHINOLINES

摘要

Thiadiazolo- and oxadiazolo-tetrahydroisoquinoline derivatives which are inhibitors of phenylethanolamine N-methyltransferase which catalyzes the final step in the biosynthesis of epinephrine. The compounds of the invention can be prepared by various methods, and in general they will be administered as pharmaceutical compositions.