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10-bromsandwicin and 10 / bromisosandwicin and acid addition salts thereof and processes for preparing these compounds
10-bromsandwicin and 10 / bromisosandwicin and acid addition salts thereof and processes for preparing these compounds
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机译:10-溴代山wi素和10 /溴代山and素及其酸加成盐及其制备方法
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摘要
10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.
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