BIOLOGICAL CELLS EXTERNALLY MODIFIED FOR CONTROLLED RELEASE,IN THE SPLEEN AND/OR LIVER,OF PHARMACEUTICALLY ACTIVE SUBSTANCES COMPRISED THEREIN,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

the effect of a beschraenkung in loaded cells entrapped drug to a specific site within the bloodstream of the body or a body (e.g., the spleen and the liver) is in accordance with the known methods, load cells was not possible.a beschraenkung effect are achieved by that, together with the interaction with the spleen and / or liver of human body substances for fabrics and the cell membrane with the produced permeabilitaet broken cells for inclusion in the z the loaded cells osmotisch activethe membrane vertraegliche substances of organic and inorganic species in the solution for material exchange zellvertraegliche provided input.this is different for inclusion of the substances and the osmotisch active substances in the loaded cells the size and / or the shape of the load cells on the size and / or the form of the original input cells, wherethe loaded cells after injection into the bloodstream of an animal or human body by the system of organs, spleen and liver from blood and isolated to be reduced. in the implementation of the procedure, depending on the erfodernissen, either by osmotic pressure permeabilitaetserhoehung exposure or exposure to an electric field....u.s.w