ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV FARMAKOLOGISK AKTL IVE AMINOPROPANOLDERIVATER AV 5-(2-HYDROKSYSTYRYL)-ISOKSAZO

摘要

ABSTRACT OF THE DISCLOSUREThe prevent invention is directed to novel amino-propanol derivatives of 5-(2-hydroxystyryl)-isoxazole of theformula (I) (I)where n is 1 or 2, o is 1, 2 or 3, R1 and R2 are each hydrogenor straight-chain or branched alkyl of 1 to 5 carbon atoms,R3 is hydrogen, hydroxyl, halogen alkyl, alkoxy or alkylthioof 1 to 5 carbon atoms, (the last-mentioned three groups eachbeing unsubstituted, or mono-, di or tri-substituted byhalogen or mono-substituted by hydroxyl or alkoxy of 1 to3 carbon atoms), alkenyl, alkynyl, alkynyloxy or cycloalkoxy,each of 2 to 6 carbon atoms in the alkyl and of 3 to 8 carbonatoms in the ring or amino which is unsubstituted or is mono-or di-substituted by alkyl of 1 to 5 carbon atoms, and if o is2 or 3, the R3's may be identical or different, or R3 ismethylenedioxy or alkylene of 3 or 4 carbon ? o , and R4is alkyl of 1 to 4 carbon atoms, and their addition saltswith acids. This invention is also concerned with thepreparation of said novel compounds, their use in the treatmentof hypertonia, coronary heart disease and cardiac arrhythmias.