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WATER-SOLUBLE, NON IONIC RADIOOPAQUE CONTRAST AGENTS (X-RAY CONTRAST AGENTS) AND PROCESS FOR THEIR PRODUCTION
WATER-SOLUBLE, NON IONIC RADIOOPAQUE CONTRAST AGENTS (X-RAY CONTRAST AGENTS) AND PROCESS FOR THEIR PRODUCTION
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机译:水溶性非离子辐射不透明造影剂(X射线造影剂)及其生产方法
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ABSTRACT OF THE DISCLOSURE.alpha., .omega.-bis-[5-(dihydroxyalkyl) aminocarbonyl-3-hydroxyacyl-amino-2,4,6-triiodo-benzoyl-amino]-oxaalkanecompounds of the formulawherein R1 isR and R' are hydrogen or methyl,R2 is dihydroxyalkyl having 3 or 4 carbon atomsn is 2 or 3,m is an integer between 1 and 5, andn(m+1) is an integer between 4 and 12,are readily soluble in water to yield injectable radio-paque contrast compositions which are well tolerated andstable. The compounds are prepared in good yields byreacting a reactive derivative of a 5-(di-hydroxyalkyl)-aminocarbonyl-3-acyloxyacylamino-2,4,6-triiodo-benzoicacid with an .alpha.,.omega.-diamino-oxaalkane of the formulaR - NH - CnH2n- (O- CnH2n) - NH - R
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