PURPOSE:To fractionate efficiently a stereoismer mixture of the titled substance useful as a drug having antiacetyl choline action, by heat-treating the titled compound in a state of stereoisomer mixture with inexpensive benzene, toluene, or xylene, utilizing the solubility difference in hot condition. CONSTITUTION:Iodinated 1-[( 2-cyclohexyl-2-phenyl-1,3-dioxolan-4-yl )methyl]- 1-methyl-piperidinium in a state of sterioisomer mixture is heated under reflux in benzene, toluene, or xylene in an amount of 10-20 times as much as that of the compound, crystals insoluble in hot condition are filtered off, to separate the stereoisomer of the titled compound. The stereoisomer mixture, for example, is prepared by subjecting 1-[(2-cyclohexyl-2-phyenyl-1,3-dioxolan-4-yl)methyl] piperidine and methyl iodide to N-quaternization reaction.
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