Procedure to obtain the factors),(b) and (c) to 40104 antibiotic Derivatives tetraalcanoilo (C2 - C6) and trialcanoilo (C2 - C6) of these factors a and b respectively and the Dihydro derivative factor

摘要

{PG,1 A-40104 antibiotic complex, comprising active factors A, B, C, and D, produced by submerged aerobic fermentation of {i Clitopilus pseudo-pinsitus. {l Individual factors, A, B, and C have been isolated. A-40104 factor C is the known antibiotic pleuromutilin. A-40104 factors A and B are novel antibiotics related to pleuromutilin. A-40104 factor A, the major new factor, is the D-xylose acetal derivative of pleuromutilin. A-40104 factors A and B, their 19,20-dihydro derivatives and the per(C{HD 2{L {14 C{HD 6{L )alkanoyl derivatives of factors A and B and of their 19,20-dihydro derivatives are active against gram-positive and gram-negative bacteria, anaerobic bacteria, and Mycoplasma.