The method and the integral analytical element for determining the concentration of a specific ionic analyte in a liquid sample

摘要

A method for the determination of an ion in a liquid sample and an analytical element for use in such determinations are disclosed. More particularly, the contemplated method comprises contacting an analytical element with the sample in the presence of a detectable species associated with an ionic analyte, said analytical element comprising a layer of substantially nonpolar material incorporated with an analyte-specific ionphore, and measuring the amount of said detectable species which has migrated to at least a surface portion of said analytical element, the amount of said detectable species which has migrated being indicative of the concentration of the specific ionic analyte in the sample. The analytical element can include a layer of substantially nonpolar material incorporated with an analyte-specific ionophore and, in laminar relationship therewith, a second layer incorporated with a detectable species associated with said ionic analyte.