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Stable d-phenylalanine-L-prolyl-L-argininal-aldehyde sulfate its preparation and use in anticoagulant active pharmaceuticals
Stable d-phenylalanine-L-prolyl-L-argininal-aldehyde sulfate its preparation and use in anticoagulant active pharmaceuticals
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机译:稳定的d-苯丙氨酸-L-脯氨酰-L-精氨酸-醛硫酸盐及其制备方法和在抗凝活性药物中的应用
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摘要
The invention relates to D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or NG-carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the NG-carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate is isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity.
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