Dimeric indole-dihydroindole compounds of the formula I …CHEM… wherein… R is OCH3, NH2, NHCH3, NHC2H5, NHC2H4OH or NH-NH2;… R1 is OH or acetoxy;… R2 is CH3 or CHO; and… R4 is ……NH-@-R5 wherein R5 is H, methyl, …??NHCOO methyl or methylthiomethyl; and their pharmaceutically-acceptable acid addition salts, active as anti-tumor agents in mammals, are prepared from their C-4 min hydroxy analogues by reaction with hydrogen cyanide or nitriles under strongly acidic conditions.
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机译：式I的二聚吲哚-二氢吲哚化合物……其中：R为OCH 3，NH 2，NHCH 3，NHC 2 H 5，NHC 2 H 4 OH或NH-NH 2;…R 1为OH或乙酰氧基;…R 2为CH 3或CHO; R 4是……NH-@-R 5，其中R 5是H，甲基，……NHCOO甲基或甲硫基甲基;和通过在强酸性条件下与氰化氢或腈反应，从其C-4 min羟基类似物制备在哺乳动物中具有抗肿瘤活性的二甲基苯磺酸盐及其药学上可接受的酸加成盐。
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