A process for the preparation of a Derivative of 2 - to fortimicina soxi - B2 - or replaced.

摘要

Process for the preparation of a Derivative of 2 - Deoxy - substituted fortimicina or B2, of formula (i), wherein R is Hydrogen, acetyl alanilo glicilo, B -, B - or lower aminoalquilo; r1 is Hydrogen, halogen, glicilamido azido, amino, or B - alanilamido, and R2 is Hydrogen or Halogen, and their salts Difficult to accept.Involves reacting a compound of formula (ii) where r have the meaning indicated already; Z is Hydrogen or a protecting Group, and the Group B represents a rest amino protected, with a compound that contains azido and chloride anion or, if desired, by Adequate procedures, thereby Nan Protection groups to form the compound of formula (i), wherein R1 is Halogen,Azido or Hydrogen, and R2 is Hydrogen or Halogen.