A procedure for the preparation of N - (1 - (alcohil or Allyl pirrolidinilmetil) - 2 - (OR) - 2 - methoxy - dimethoxy 2,3) - 5 - (substituted sulfamoyl or sulfamoyl) - benzamides

摘要

Process for producing N - (1 - (alcohil oalil) - 2 - pirrolidinilmetil) - 2 - methoxy (OR 2,3 dimethoxy) - 5 - (substituted sulmamoil or sulfamoyl) - benzamides, of formula (i), wherein R1 is a alcohilo Allyl radical or C14; R2 is Hydrogen Atom or a methoxy radical; R3 and R4 are Hydrogen Atoms. Alcohilo or radical.Involves the reaction of the acid - 2 - methoxy - (OR 5 - dimethoxy 2,3 - chlorosulfonyl) benzoic acid with thionyl chloride in a mixture of water and 1,2 - DICHLOROETHANE, reflux temperature, followed by the amidificacion with an Amine of formula (ii) in a Solvent at temperatures within acuoorganico 3 0 5 C and CSubsequent Treatment of the obtained with a compound of formula (iii) to mine at lower Ambient temperatures; formulas in which R1, R3 and R4 have the same meaning as in formula (i).