5,10-Dioxo-5,10-dihydrodiimidazo(1,5-a,1',5'-d)pyrazine-1,6-dicarboxylic acid and a process for producing imidazoledicarboxylic acid amido-derivatives

摘要

A novel compound, 5, 10-dioxo-5, 10-dihydrodiimidazo [1, 5a, 1 min , 5 min d] pyrazine-1, 6-dicarboxylic acid having the following formula …CHEM… is provided, which may be used as a good reactive derivative of alpha , beta -imidazoledicarboxylic acid and is particularly a good reactant for modifying amino group-containing compounds. …??For producing the desired imidazoledicarboxylic acid derivative having the following formula …CHEM… wherein R is selected from the group consisting of a hydrogen atom, an alkyl group, aralkyl group, aryl group, specifically a group …CHEM… in which X is a hydrogen atom or a hydroxyl group, and an organic residue, such as a heteroaromatic group, which groups may optionally carry substituent groups, and A is an organic residue having one of the following formulae: …CHEM… wherein Z is selected from the group consisting of a hydrogen atom, an acyloxy group, preferably an acetoxy group, carbamoyloxy group, heteroaromatic thio group, preferably a 5-(1-methyltetrazolyl) thio group and quaternary ammonium group, preferably a substituted or unsubstituted pyridinium-, quinolinium- or picolinium-group, the above-defined imidazoledicarboxylic acid derivative of the formula I is reacted with a compound having the following formula NH2-@H-COA…… wherein A and R are as defined above.