Process for the preparation of reactive thyroid gland hormones T3 and T4 derivatives that are capable of coupling, and their use

摘要

To produce reactive, couplable derivatives of the thyroid hormones 3,3 ', 5-triiodothyronine (T3) and 3,3', 5,5'-tetraiodothyronine (T4), all functional groups of the thyroid hormone are silylated with a reactive triorganosilyl derivative and set the persilylated derivative of the thyroid hormone obtained with an activated carboxylic acid derivative. The compounds obtained are suitable for the preparation of insoluble derivatives by coupling with polymeric supports or copolymerization with unsaturated monomers.