Allyl isothiocyanate and vegetable oil contg. compsn. - having rubefacient activity

摘要

A pharmaceutical compsn. comprises allyl isothiocyanate (I) and a vegetable oil. The compsn. is for topical use. (I) is generally used as an oil of mustard or of horseradish, and the compsn. may e.g. contain 1 pt. of oil of mustard to 50-1000 pts. of a vegetable oil such as olive, peanute, corn, soya or girasol oil. The compsn. is generally applied to a dressing which is positioned over the affected part and then compressed against the skin. For certain treatments, an orbital compression chamber such as that disclosed in U.S. Pat.No.4193401 may be used. (I) may be used in conjunction with another drug such as an antibiotic and when thus used it not only provides a greater blood flow but also a greater absorption of the other drug. The compsn. helps to increase the blood flow to an internal injury, inflammation or diathesis. The vegetable oil attenuates undesirable effects of (I) and allows (I) to be maintained on the body for a longer period of time than compsns. contg. (I) in alcohol.