Trans-4-(aminomethyl)-cyclohexanecarboxylic acid derivs. (I) and their salts are new. In (I) R is CnH2n+n'-CO; n = 4-20; and n' = +1, -1, -3 or -5. (I) are N-acyl derivs. of tranexamic acid and are useful as antitumour agents. Their anti-tumour activity is greater than that of tranexamic acid itself (cf. JAMA 1977, 238(2), 154-155) but the freedom from side-effects is the same as that of tranexamic acid. Results of pharmacological tests are given in the specification. Thus N-linoleyl-tranexamic sodium salt (mouse LD50 4.5 g./kg. s.c., 3.0 g./kg. i.p. or 8.0 g./kg. p.o) when administered 10 times i.p. in a dosage of 30 mg./kg. or 20 times p.o. in a dosage of 150 mg./kg. gives 100% survival of mice with transplanted sarcoma 180 cells (1 x 106 cells/animal), whereas survival in control animals was only 80%.
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机译：反式-4-（氨基甲基）-环己烷羧酸的衍生物。 （I）及其盐是新的。在（I）中，R为C n H 2n + n’-CO; n = 4-20;并且n'= + 1，-1，-3或-5。 （I）是N-酰基衍生物。氨甲环酸是一种抗肿瘤药。它们的抗肿瘤活性大于氨甲环酸本身（参见JAMA 1977，238（2），154-155），但无副作用与氨甲环酸相同。说明书中给出了药理试验的结果。因此，当腹膜内给药10次时，N-亚油酰基-氨甲环肟酸钠盐（小鼠LD50为4.5g./kg s.c.，3.0g。/ kg.ip。或8.0g./kg.p.o）。剂量为30 mg./kg。或每次20次剂量为150 mg./kg。移植肉瘤180细胞（1 x 106细胞/动物）的小鼠的存活率为100％，而对照动物的存活率仅为80％。
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