Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.

摘要

Isoquilins derivs. of formula (I) (in the (R)- or (S)- form or mixts. and their acid addn. salts are new: In (I), R' is -(CH2)n-OR2 in which R2 is 1-8C alkyl and n is 1 or 2. (I) have analgesic, anti-inflammatory and antipyretic activie. The (S)-isomers also have antiviral activity (esp. against rhinoviruses). Acute toxicity is low.