B LYMPHOCYTIC CELLULAR STRAIN (BS1-2-SY) FOR PREPARING HIGH-FREQUENCY SISTER CHROMATIDAL EXCHANGE FACTOR FROM PATIENT OF HIGHLY CARCINOGENIC GENETIC DISEASE BOLOOM'S SYNDROME

摘要

PURPOSE:The titled B lymphocytic cellular group (BS1-2-SY), obtained by reacting an Epstein-Barr virus (EB virus) with a lymphocytic cell separated from a material in a patient of a highly carcinogenic genetic disease Bloom's syndrome, and useful for treating and preventing cancer and leukemia. CONSTITUTION:A blood collected from a material in a patient with Bloom's syndrome which is a highly carcinogenic genetic disease is centrifuged, and an Epstein-Barr virus (EB virus) is then absorbed in the resultant lymphocytic cell and then inoculated into Roswell Park Memorial Institute medium-1640 (RPMI- 1640) culture medium containing a bovine fetal blood serum and a human neonatal navel cord blood serum and cultivated in a CO2 cultivating tool to give the aimed B lymphocytic cellular strain (BS1-2-SY), having the membrane surface of the cellular strain positive to an immunoglobulin, and capable of preparing a high-frequency sister chromatidal exchange factor which is a genetic character of the individual patient.