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PROCESS FOR PRODUCING TRIPEPTIDE-AMIDES TRH-ANALOGUES,EFFECTIVES ON THE CENTRAL NERVE SYSTHEM
PROCESS FOR PRODUCING TRIPEPTIDE-AMIDES TRH-ANALOGUES,EFFECTIVES ON THE CENTRAL NERVE SYSTHEM
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机译:三肽酰胺类TRH类似物的生产过程,对中枢神经系统的影响
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摘要
The invention relates to new peptide derivatives which act on the central nervous system and correspond to the general formula (I), Glp-X-Y-NH-A (I) wherein X is L-norleucyl, L-leucyl, L-norvalyl, D-leucyl, L-prolyl, L-2-aminobutyryl, L-valyl, L-threonyl, L-isoleucyl, L-2-aminodecanoyl, L-cyclohexylalanyl or L-tert.-butyl-seryl group and Y is L-prolyl group, or X is L-histidyl group and Y is L-homoprolyl or D-pipecolyl group, furthermore A is hydrogen, a C1-10 alkyl group or a C1-3 alkyl group having a dimethylamino substituent, with the proviso that if X is L-leucyl group, A is other than hydrogen, and pharmaceutically acceptable complexes thereof. These compounds are prepared by methods commonly applied in the peptide chemistry.
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