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NEW AMINO ISOMERS, PREPARATION AND THEIR APPLICATION IN MEDICINE
NEW AMINO ISOMERS, PREPARATION AND THEIR APPLICATION IN MEDICINE
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机译:新氨基同分异构体,制备方法及其在医学中的应用
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摘要
The (-)-D-isomers of compounds of the general formula IMAGE (I) in which X stands for an acidic radical, especially a radical of phosphonic acid, sulphonic acid, boronic acid or tetrazole, R stands for an alkylene, alkenylene or alkynylene radical with 3 or more carbon atoms, preferably 3 to 6 carbon atoms, or a C3 to C7 cycloalkyl radical, and A and B independently of each other stand for a hydrogen atom or a lipophilic radical, especially an ester radical, or salts thereof, or pharmaceutically acceptable bioprecursors thereof, especially (-)-D-aminophosphonopentanoic acid and (-)-D-aminophosphonoheptanoic acid, find use in the treatment of diseases of the central nervous system. The compound aminophosphonoheptanoic acid is also novel as a racemic mixture and the present invention also relates to that compound in racemic form which may be used in the same way as the said (-)-D-isomers.
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