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Acids 6,11 - dihydro - 11 - oxodibenz (b, e) oxepinalcanoiques and their esters, their process of preparation and their use
Acids 6,11 - dihydro - 11 - oxodibenz (b, e) oxepinalcanoiques and their esters, their process of preparation and their use
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机译:酸6,11-二氢-11-氧代苯并(b,e)氧代癸酸酯及其酯,其制备方法和用途
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摘要
6,11-Dihydro-11-oxodibenz[b,e]oxepinealkanoic acids of the formula I, their C1- to C4-alkyl esters and the pharmacologically compatible salts are prepared. An alpha -bromo-2-toluylic ester which is optionally substituted by halogen, C1- to C4-alkoxy, C1- to C4-alkyl or trifluoromethyl is reacted with an alkyl ester of a hydroxyphenylacetic acid. The resulting diester is hydrolysed, cyclised and, where appropriate, converted into the corresponding alkyl ester. The resulting compounds can be used as anti-inflammatory and analgesic agents. IMAGE
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