PROCESS FOR PREPARING ANGIOTENSIN II ANALOGUES CONTAINING ALPHA-HYDROXY-ACID IN POSITION 1 WITH ANGIOTENSIN II ANTAGONIST ACTIVITY

摘要

Novel Angiotensin II peptides of the formula: X-Arg-Val-Tyr-Ile-His-Pio-Y where X is hydroxyacetyl or alpha -hydroxypropyl and Y is leucyl, isoleucyl, alanyl or threonyl or an acid addition salt or a complex thereof are disclosed and a process for the preparation thereof are disclosed having the ability to lower renal hypertension.