guaiacol esters of alpha - and betamercaptopropionylalanin and alpha - and betamercaptopropionylglycin, procedures to their manufacture and pharmaceutical compositions containing them.

摘要

Guaiacol esters of alpha- and beta-mercaptopropionyl alanine and of alpha- and beta-mercaptopropionyl glycine having formulae: …CHEM… wherein R is hydrogen or methyl and Y is hydrogen or an acyl radical (acetyl, benzoyl or methoxycarbonyl). …??Pharmaceutical compositions containing these guaiacol esters have mucolytic activity. …??The process for manufacturing these guaiacol esters comprises preparing in a known per se manner a sulhydryl group-containing intermediate wherein the sulfhydryl is protected by a trityl or p-methoxybenzyl group, and removing the protective group under acid conditions.