Procedure for obtaining derivatives from (2-oxo-pirrolidine-1) and from (2-oxo-piperidine-1) -acob carboxylic (organic acid) (Machine-translation by Google Translate, not legally binding)

摘要

Process for the obtaining of derivatives of the (2-oxo-pirrolidine-1) - and the (2-oxo-piperidin-1) -acido carboxylic (organic acid), of formula (I), in which ryr, are hydrogen or rent c 003; m well from 0 to 4 and n from 1 to 2; and r is hydrogen or a radical of formula (II), in which r, r, m and n have the same meaning as in formula (I). It consists of the ring closure of compounds of formula (III), where r, r, m and n are the same as in formula (I), and is halogen; and r and r can be various radicals, to form an oxopirrolidine or an oxy-piperidine. The reaction is carried out in the presence of a base at a temperature between 20ºc and 100ºc; or through hydrolytic separation, through phase transfer. These compounds have pharmacological applications for the treatment of amnesia and ischemia and for their nootropic effect. (Machine-translation by Google Translate, not legally binding)