A method for the preparation of Peptide antagonists of the hypothalamic hormone.

摘要

A method for the preparation of peptides from a hypothalamic Hormone antagonists. It consists of the following Operations: 1) make Short peptides or amino acids to form a linear Chain of intermediate Compound (i).2) to eliminate one or more of the groups x 1 to X Protectors 4 Intermediate Compound by Treatment with HF or equivalent, at a temperature of 0 C and / or Cleave the Peptide Resin bracket included in any x 5. 3) If you want to convert a Peptide, resulting in a non-toxic Salt thereof. Gets the compound (ii).Inhibit the secretion of gonadotropins from the pituitary gland and inhibit the release of steroids by the gonads.